SC5 Heinrich Hofmann

Short Course on
“Inorganic Nanoparticles for Medical Applications: physical, chemical and biological aspects”

by Heinrich Hofmann and Margarethe Hofmann-Amtenbrink

Nanoparticles are used in diagnostics, in drug discovery and in the targeted drug formulation and in several therapies like cancer, inflammatory diseases or brain diseases. Furthermore, as diagnostic tools based on nano- and/or microtechnologies become more sophisticated, there is a need for an improved understanding of the physico-chemical properties of these devices in order to further their development and use them correctly.

10:00 – 10:30 Registration
10:30 – 11:30 Session 1. a) Short Introduction in medical unmet needs: cancer, inflammatory diseases, CNS b) Introduction Phsical and Chemical  Properties of Nanoparticles.  Effect of size on electronic structure, quantum confinement. Magnetic properties (superparamagnetism). Thermodynamic and chemical properties. Synthesis of nanoparticles (Iron oxide, gold, core shell)
11:30 – 11:45 Coffee break
11:45 – 12:45 Session 2.Colloidal behaviour of nanoparticles.  Introduction into colloidal forces, DLVO, depletion forces; Suspension with nanoparticles, Important parameters for characterisation of nanoparticles in biofluids
12:45 – 14:00 Lunch break (lunch not included)
14:00 – 15:00 Session 3. Particle – cell interaction. Particle – protein corona, Up-take mechanism, Toxicology,
15:00 – 15:15 Coffee break
15:15 – 16:15 Session 4. Application of nanoparticles, legal and social issues. Contrast agent for MRI, molecular imaging, Hyperthermia, drug/gene delivery, Nanoparticle as diagnostic tool,

Handouts: Copies and CD of all slides in the PowerPoint format will be provided at the beginning of the SC.

Speaker: Hofmann Heinrich, Prof. Dr.-Ing. Studied Material Science and Engineering at the Technical University of Berlin. 1983 he got his PhD in Material Science with a thesis prepared at the Powder Metallurgy Laboratory at the Max Planck Institute in Stuttgart. Between 1983 and 1985, he was senior scientist at the same Max Planck Institute working on novel hard metals and composites.  In 1985 he joined the R&D center of Alusuisse-Lonza Services AG, at Neuhausen-am-Rheinfall. In 1993 he joined the Swiss Federal Institute of Technology as Professor and Director of the Powder Technology Laboratory at the Department of Materials Science and Engineering. His research area includes the synthesis of nanostructured materials based on nanoparticles and the modification of surfaces with nanoparticles using colloidal methods. The application of such materials is in the medical and biological field (drug delivery, hyperthermia, cell separation, biosensors), electronics and sensors as well as coating of medical devices, turbine blades and paper. He is member of the Swiss Federal working group “Nanoregulation”. Since 2006 he is director of the research unit “Surface, Coating and Particle Engineering” SPERU of the Competence Centre of Material Science. He is member of various scientific advisory boards in Japan, China and Thailand. Since 2008 he is a cofounder of a company developing nanocomposites for cancer treatments (ANTIA Therapeutics). His publication list comprises over 120 Publications in reviewed journals, 33 publications in proceedings, co-author of 4 books and co-editor of 2 MRS proceedings and he is co-inventor of 15 patents or patent applications. Additionally he has given more than 20 invited and key note lectures on particles synthesis, modification and nanoparticles in biomedical applications in EU, US Australia and Asia.

Speaker: Hofmann-Amtenbrink, Margarethe, Dr.-Ing. Studied Material Science and Engineering at the Technical University of Berlin. 1984 she got her PhD in Material Science with a thesis prepared at the Powder Metallurgy Laboratory at the Max Planck Institute in Stuttgart. In 1987 she started her own business (Mat Search Consulting Hofmann) in Switzerland. Among various consulting activities for industry she became CEO of the Swiss governmental Priority Program for Materials (PPM 1991-1994), CEO of the Swiss Association for Materials Technology, SVMT and is still CEO of the Foundation for Rare Metals, ESM. From 2003 to 2009 she was chairperson of the Biotechnology Advisory Board of the AO Foundation Davos, Switzerland and as such responsible for a research program of about 1 Mio per year. Since about 10 years she is involved in research projects on nanoparticles for biomedical applications and initiated two European Research Projects (FP5 and FP7) for which she was/is the scientific coordination. She is member of several Advisory Boards in Germany and Switzerland and individual member of the Swiss Academy for Engineering Sciences, SATW, Switzerland and has become member of ETP Nanomedicine. M. Hofmann-Amtenbrink has published several reports in the field of technology assessment and innovation and published book chapters and articles in the field of biomedical nanotechnology.